Computational model of midbrain dopaminergic neuron activity in ageing and obesity
نویسندگان
چکیده
منابع مشابه
Transcriptional control of midbrain dopaminergic neuron development.
Although loss of midbrain dopaminergic neurons is associated with one of the most common human neurological disorders, Parkinson's disease, little is known about the specification of this neuronal subtype. Hence, the recent identification of major transcriptional determinants regulating the development of these neurons has brought much excitement and encouragement to this field. These new findi...
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Background and Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease that affects 3% of the population. PD involves a progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and subsequent loss of dopamine. Dopamine depletion leads to movement dysfunction and is accompanied with tremor, rigid muscle...
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The relatively few dopaminergic (DA) neurons in the mammalian brain regulate many important neural functions, including motor integration, neuroendocrine hormone release, cognition, emotive behaviors and reward. A number of laboratories, including ours, have contributed to unravel the mechanisms of DA phenotype induction and maturation and elucidated the role of epigenetic factors involved in s...
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Neurons synthesizing the neurotransmitter dopamine exert crucial functions in the mammalian brain. The biggest and most important population of dopamine-synthesizing neurons is located in the mammalian ventral midbrain (VM), and controls and modulates the execution of motor, cognitive, affective, motivational, and rewarding behaviours. Degeneration of these neurons leads to motor deficits that ...
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INTRODUCTION Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually dwell in regions distinct from their origin. From ventricular zones, neurons and/or neuronal progenitors navigate along diverse courses, radially and tangentially, to their final destination and integrate into specific brain circuits (Corbin et al., 2001; Hatten, ...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2013
ISSN: 1471-2202
DOI: 10.1186/1471-2202-14-s1-p85